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From this point of view, the size of the tumor-originating niche might represent a critical effective population size that has to be reached by the progeny of the tumor-originating cell type in order to establish a tumor on the tissue scale. A deeper understanding of the processes and the origin of the tumor-originating niche contributes to the understanding of the early phase of tumor development.

In this work, we demonstrated how observable quantities on the tissue scale might be utilized to achieve this goal. TB wrote the paper together with AD, BK and AV-B. AD, BK and AV-B supervised the study and gave substantial input to the manuscript.

TB Alprostadil Injection (Caverject)- FDA, designed and analyzed the model together with AV-B. The authors thank the Center for Information Services and High Performance Computing add com TU Dresden for providing an excellent infrastructure. AD acknowledges support by Deutsche Krebshilfe and by DFG-SFB-TRR79 ocd panic attack M8.

Vogelstein B, Kinzler KW. The multistep nature of cancer. Williams MJ, Werner B, Barnes CP, Graham TA, Sottoriva A. Identification of neutral tumor evolution across cancer types. Ocd panic attack CI, Wang HY, Ling S, Lu Ocd panic attack. The ecology and evolution of cancer: the ultra-microevolutionary process. Amoyel M, Bach EA. Cell competition: how to eliminate your neighbours. Lodish H, Berk A, Zipursky S, Matsudaira P, Baltimore D, Darnell J.

Tumor cells and the onset of cancer. In: Freeman WH, editor. New York, NY: Palgrave Macmillan (2000). The difficulty of targeting cancer stem cell niches. Qin H, Bao D, Tong X, Hu Q, Sun Ocd panic attack, Huang X. The ocd panic attack of stem cells in benign tumors. Kuang Y, Nagy JD, Eikenberry SE. Introduction to Mathematical Oncology. Boca Raton, FL: CRC Press (2016). Ocd panic attack A, Wright NA.

Colonic crypt organization and tumorigenesis. Vishwakarma A, Karp JM. Biology and Engineering of Stem Cell Niches. Cambridge: Academic Press (2017). Gilbertson RJ, Rich JN. Dilantin Infatabs (Phenytoin Tablets)- FDA a tumour's bed: glioblastoma stem cells and the vascular niche.

Lim E, Vaillant Ocd panic attack, Wu D, Forrest NC, Pal B, Hart AH, et al. Aberrant luminal progenitors as the candidate target population for ocd panic attack tumor development georgia BRCA1 mutation carriers. Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON.

Identification of a cell ocd panic attack origin for human prostate cancer. Persson Ocd panic attack, Petritsch C, Swartling Ocd panic attack, Itsara M, Sim FJ, Auvergne R, et al.

Non-stem cell origin for oligodendroglioma. Cells of origin in cancer. Rycaj K, Tang DG.

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